CBL and leukemia: Given the frequent crosstalk between PTMs [60, 61]—such as PRL2 dephosphorylating the tyrosine 371 site of the E3 ubiquitin ligase CBL, thereby reducing CBL-mediated ubiquitination and FLT3 degradation, which in turn enhances FLT3 signalling in leukaemia cells [62]—an improved algorithm that incorporates the relationships amongst different PTM types could significantly increase prediction accuracy.