Among these genes, AGAP3, CDK2, DMKN, PRMT1, PSMA7, POU4F1, RAB15 and SNAI1 were up-regulated in tumor tissue compared with normal tissue in TCGA-COAD cohort, while the remaining genes were down-regulated in tumor tissue (Figure 9A). The gene discussed is PRMT1; the disease is neoplasm.