Herbal compound prescriptions, such as Wumei Pill, STW 5-II, QingHuaZhiXie Prescription, Sancao Lichang Decoction, CKF, Xiaoyaosan, improvement of inflammation, defecation abnormalities, VHS and depressive behavior in IBS, via suppressed TLR4, TLR4/MyD88/NF-κB or TLR4/NF-κB/NLRP3 signal pathway (45–47, 54, 55, 57). Here, NLRP3 is linked to irritable bowel syndrome.