Administration of 3-deazaneplanocin A (3-DZNeP) in mouse models of CG- or HG-PDF-induced peritoneal fibrosis has been shown to mitigate peritoneal injury by reducing CD68+ macrophage invasion and angiogenesis through the inhibition of EZH2 methylation activity. This evidence concerns the gene EZH2 and Peritoneal Fibrosis.