In dihydrotestosterone (DHT)-induced PCOS-like female mice, DHT up-regulates ACE2 mRNA in the lung, cecum, heart and kidney, which synergizes with host transmembrane protease serine 2 (TMPRSS2) to facilitate SARS-CoV-2 viral entry into the host cells (115). Here, TMPRSS2 is linked to polycystic ovary syndrome.