The adverse cardiovascular effects of PCOS could be attributed to the over-activation of the norepinephrine-NF-κB pro-inflammatory signaling pathway, contributing to increased expression of a hematopoietic progenitor retention factor, vascular cell adhesion molecule 1(Vcam1), in splenic macrophages, subsequently resulting in increased circulating total monocytes and inflammatory monocytes. This evidence concerns the gene VCAM1 and polycystic ovary syndrome.