NFKB1 and polycystic ovary syndrome: The adverse cardiovascular effects of PCOS could be attributed to the over-activation of the norepinephrine-NF-κB pro-inflammatory signaling pathway, contributing to increased expression of a hematopoietic progenitor retention factor, vascular cell adhesion molecule 1(Vcam1), in splenic macrophages, subsequently resulting in increased circulating total monocytes and inflammatory monocytes.