NAFLD-like hepatic pathological changes such as steatosis, inflammatory cell infiltration, necrotic hepatocytes, and liver fibrosis, accompanied by increased expression of inflammatory cytokines (TNF-α, IL-1β), stress-related protein urocortin-1, antioxidant gene glutathione peroxidase-1 (Gpx1), and the NLRP3 inflammasome within the hepatic tissues, have been observed in several rodent models of PCOS (108–111). The gene discussed is GPX1; the disease is polycystic ovary syndrome.