reported that Shaoyao-Gancao Decoction (SGD), commonly used to treat multiple gynecological disorders such as dysmenorrhea, adenomyosis, and PCOS, modulated gut microbiota composition, and alleviated chronic low-grade inflammation by downregulating cytokines including IL-18, IL-1β, IL-6, and TNF-α in both serum and ovarian mRNA expression in PCOS rats (238). The gene discussed is IL18; the disease is polycystic ovary syndrome.