The mechanism involves the interaction of the bile acid metabolite GDCA with the intestinal inherent (innate) group 3 lymphocytes GATA binding protein 3(GATA3), resulting in reduced secretion of the anti-inflammatory regulator IL-22.The therapeutic potential of IL-22 has been demonstrated and its administration shown to ameliorates IR, ovarian dysfunction, and infertility in PCOS (173). The gene discussed is GATA3; the disease is polycystic ovary syndrome.