These data demonstrate that during the progression of E. multilocularis infection, the regulatory activities of immune organs, particularly the liver and spleen, necessitate substantial recruitment of Ghrelin, potentially inhibiting gastrointestinal Ghrelin secretion through a negative feedback mechanism of the “gastrointestinal-brain-liver axis.” This suggests a regulatory role of Ghrelin on organ function and inflammatory response throughout the infection process. The gene discussed is GHRL; the disease is infection.