Herein, we identified 10 biomarkers (COL1A1, COL1A2, COL5A1, COL5A2, LUM, MFAP5, MXRA5, THBS2, BTG2, and CD34) for diagnosing CAVD associated with diabetes. This evidence concerns the gene COL5A1 and congenital bilateral aplasia of vas deferens from CFTR mutation.