Herein, we identified 10 biomarkers (COL1A1, COL1A2, COL5A1, COL5A2, LUM, MFAP5, MXRA5, THBS2, BTG2, and CD34) for diagnosing CAVD associated with diabetes. Here, COL1A1 is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.