Herein, we identified 10 biomarkers (COL1A1, COL1A2, COL5A1, COL5A2, LUM, MFAP5, MXRA5, THBS2, BTG2, and CD34) for diagnosing CAVD associated with diabetes. Here, CD34 is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.