TNF and Hyperglycemia: Figure 10 (top panel) shows that 7,14, or 28 days of hyperglycemia did not cause any significant changes in the gene expression of IL-6, TNF-α, or IL-10 in the lacrimal gland, but a significant decrease in the expression of IL-1β, and CCL2 was observed. Figure 10 (middle) panel shows that hyperglycemia did not cause any significant changes in the gene expression of IL-1β, IL-6, TNF-α, and CCL2 in the conjunctiva, but a significant increase in IL-10 expression was noted at 14 days of hyperglycemia.