To test this hypothesis, we quantified the gene expression of macrophage-secreted cytokines (IL-1β, IL-6, TNF-α, IL-10) and chemokines (CCL2) in the lacrimal gland, conjunctiva and cornea of non-diabetic normoglycemic mice and diabetic mice with 7, 14, and 28 days of hyperglycemia. The gene discussed is TNF; the disease is Hyperglycemia.