Overexpression of the receptor tyrosine kinases, such as human epidermal growth factor receptor 2 (HER2), insulin growth factor receptor 1 (IGFR1), and fibroblast growth factor receptor-4, contributes to around 30%–40% of BC, leading to PI3K/AKT pathway and MAPK pathway signaling that converges toward the activation of p70S6K1-assisted translation controlled regulation of cyclin D1 expression (Huynh et al., 2017; Berns et al., 2007; Nahta et al., 2005; Ritter et al., 2007; Scaltriti et al., 2007; Bange et al., 2002). Here, RPS6KB1 is linked to breast cancer.