For example, the ROC curve analysis showed that a plasma BDNF level of 2,100 pg/mL had 87.5% sensitivity and specificity in predicting complications in SCA, while Ang-2 levels of 8,845 pg/mL were 90% sensitive and 80% specific for predicting vascular complications. The gene discussed is ANGPT2; the disease is autosomal dominant cerebellar ataxia.