GSTM1 and Schnyder corneal dystrophy: Chronic inflammation and cell-free Hb drive IL-12p40 output, while IL-16 acts as a chemoattractant (Vignali and Kuchroo, 2012), regulating immune responses and contributing to leukocyte recruitment and vaso-occlusive crises in SCD (Wu et al., 2023; Kaser et al., 2000; Morikis et al., 2021).