Brain-derived Neurotrophic Factor (BDNF), a nerve growth factor, plays a crucial role in neuronal survival, adaptation, and response to ischemic brain injury, with implications for endothelial cells (ECs) survival and neo-angiogenesis in ischemic tissues (Hyacinth et al., 2012; Chen et al., 2013; Bathina and Das, 2015; Kim and Winstein, 2017; Ramaswamy et al., 2009). Here, BDNF is linked to brain injury.