Inflammatory maker ratios such as BSNF:CCL11, VEGFA:PIGF and ICAM 1:VCAM 1, which achieved AUC values of 1.0 signify an ideal biomarker, which further emphasizes their potential for distinguishing SCD patients from controls, particularly in relation to neuroinflammatory and vascular complications. This evidence concerns the gene CCL11 and Schnyder corneal dystrophy.