The CCL11:IL-12p40 ratio showed a moderately significant mean increase in HbSS patients compared to controls (0.7090 ± 0.437 vs. 0.4030 ± 0.142, p = 0.049), highlighting an inflammatory imbalance potentially linked to the immune dysregulation in SCD (Supplementary Figure S7C). This evidence concerns the gene CCL11 and Schnyder corneal dystrophy.