Assessing biomarkers like BDNF, Ang 2, CXCL10, CCL11, TNF-α, IL-6, ICAM1, VCAM1, Tie 2, and VEGFA could inform therapeutic strategies and Table 2 summarizes the detailed roles and functions of these biomarkers associated with SCD. This evidence concerns the gene ICAM1 and Schnyder corneal dystrophy.