Inflammatory maker ratios such as BSNF:CCL11, VEGFA:PIGF and ICAM 1:VCAM 1, which achieved AUC values of 1.0 signify an ideal biomarker, which further emphasizes their potential for distinguishing SCD patients from controls, particularly in relation to neuroinflammatory and vascular complications. Here, PIGF is linked to Schnyder corneal dystrophy.