Additionally, factors such as Serine/threonine/tyrosine interacting protein (STYX), MiR-223, MiR-92b-3p, FAM83D, USP9X, and KDM5c indirectly regulate various oncoproteins by modulating FBXW7 expression, contributing to CRC cell proliferation and apoptosis (Khan et al., 2018; Liu Z. et al., 2021; Gong et al., 2018; He et al., 2019; Mu et al., 2017; Lin H. et al., 2020). Here, FBXW7 is linked to colorectal carcinoma.