Influence IL-1R1 expression, sustain IL-17 production, regulate homeostasis of γδ T17 cells. Regulate γδ T cell motility and localization in the gut epithelial layer, essential for gut immunosurveillance.Regulate IL-17 release by γδ T cellsExpress TLR2, directly stimulate γδ Tcells, positively affect colitis.Increase TLR2 expression, improvebarrier functions via γδ T cells. The gene discussed is IL1R1; the disease is colitis.