It is worth noting, the diet high in acetate and lesser butyrate level in non-obese diabetic (NOD) mice model of T1DM decreased the frequency of autoreactive CD8+ T cells and increased the number of CD4+Foxp3+ Treg cells in the spleen and colon, but there was no change in the peripheral lymph nodes (Mariño et al., 2017). Here, FOXP3 is linked to type 1 diabetes mellitus.