In our study, approximately two-thirds (66%, 633 out of 952) of SCH patients with TSH levels between 4.01 and 10.00 mIU/L demonstrated an exaggerated TSH response in the TRH stimulation test, revealing true hypothyroid state and one-third (34%) of SCH patients showed normal response. This evidence concerns the gene TRH and spindle cell hemangioma.