Chorioamnionitis, an inflammation of the amniotic membrane, is commonly associated with intrauterine infections and induces the production of pro-inflammatory cytokines, such as IL-6 and interleukin-1 beta (IL-1β), which stimulate uterine contractions and contribute to the weakening of the fetal membranes [11]. The gene discussed is IL1B; the disease is chorioamnionitis.