CD8A and neoplasm: In non-smokers, resistance to immunotherapy has been related to the development of multiple sub-clones, increased infiltration of immunosuppressive cytokines, Tregs and TAMs (106), reduced CD8+ T-cell infiltration, reduced TMB/neoantigen load, and a reduced interferon-gamma signature—all culminating in an inert tumour microenvironment (24, 107).