Conversely, the absence or decreased levels of lysine-specific demethylase 1A (LSD1), along with increased PD-L1 K162 methylation and SET domain-containing lysine methyltransferase 7 (SETD7) expression, have been associated with anti-PD-L1 resistance in NSCLC (101). Here, SETD7 is linked to non-small cell lung carcinoma.