In previous studies, L02 cell line has been used to validate that curcumin ameliorates bisphenol A-induced insulin resistance by inhibiting the JNK pathway (45), to demonstrate that mitochondrial oxidative stress-induced hepatic insulin resistance can be mitigated by sphingosine 1-phosphate (46), as well as to assess the effects and mechanism of substances such as pterostilbene and Annexin A1 on hepatic insulin resistance (47, 48). Here, MAPK8 is linked to Insulin resistance.