In previous studies (a total of 477 papers in PUBMED searching, using the key words “L6 cells, insulin resistance”), L6 cells have been employed to explore the role of NF-κB activation in the development of insulin resistance (70), to study the mechanism of HM-chromanone in alleviating obesity-related insulin resistance (71), and to assess the impact of metformin on attenuating insulin resistance (72). This evidence concerns the gene NFKB1 and Insulin resistance.