SOCS1 and Insulin resistance: For instance, studies using HepG2 cells have demonstrated that early growth response proteins-2 (Egr2) enhances insulin resistance via JAK2/STAT3/SOCS-1 pathway (27), PKM2 may promote hepatic insulin resistance via STAT3 pathway (28), and ASGR1 is a potential intervention target for improving systemic insulin resistance (29).