The diagnostic analysis of different factors, including plasma biomarkers (NfL and P-tau181), OCT parameters (RNFL and GCIPL) and clinical factors (age, years of education) to discriminate moderate CIND/dementia (high risk of cognitive decline) from NCI/mild CIND participants (low risk of cognitive decline), are shown in Table 3. The gene discussed is NEFL; the disease is dementia.