PLXNA2 and dementia: We found that the tri-model (combining OCT + plasma + clinical; AUC = 0.81) significantly outperformed single factors (P = 0.001) but performed similarly to the duo-model (plasma + clinical) in discriminating between moderate CIND/dementia and NCI/mild CIND (AUC = 0.79; P = 0.029, not significant after Bonferroni adjustment).