APP and early-onset autosomal dominant Alzheimer disease: This link between Aβ-related mutations and tau pathology agrees with the previous findings of APP mutations correlating with pathological tau aggregation in iPSC-derived neuronal models of Alzheimer’s disease,52 not only showing that iPSC-derived neuronal models are valuable models to study the pathophysiology of Alzheimer’s disease but also supporting the amyloid cascade hypothesis.