MAPT and early-onset autosomal dominant Alzheimer disease: Meanwhile, in the post-mortem human Alzheimer’s disease brain samples, the areas of the Aβ (D = 0.06, P < 0.001) and AT8-positive tau (D = 0.12, P < 0.001) aggregates were larger in the homogenized samples, indicated by a rightward shift in the cumulative area distribution plots (Fig. 6F and G), but the difference in average aggregate area only reached significance for the tau aggregates (CI95Aβ = −123.10, 279.15; CI95pTau = 7902.78, 12 463.25).