FBXW7 and renal cell carcinoma: Moreover, Polo-like kinase 1 (PLK1) stimulates the phosphorylation and degradation of FBXW7,and a related study found that under the combination of Bcl-2 (ABT199) and PLK1 (BI2536) inhibitors, tumor cells exhibiting low expression of FBXW7 and overexpression of c-MYC can induce RCC cells into apoptosis (Fan et al., 2022).