TP53 and renal cell carcinoma: One related study demonstrated that RBCK1 promoted the polyubiquitination and degradation of p53 by directly interacting with it, and RBCK1 depletion affected proliferation, apoptosis, and cell cycle arrest in RCC cells, possibly due to RBCK1-mediated ubiquitination and degradation of p53 (Yu et al., 2019).