FBXW7 is one of the top 10 mutated genes commonly found in metastatic RCC cells, and it can also mediate the degradation of NFAT1, which can improve PD-L1 expression by increasing TNF levels in RCC, fostering RCC proliferation, and modulating immune responses through diverse signaling pathways (Liu et al., 2022b). Here, NFATC2 is linked to renal cell carcinoma.