ADAMTS5 and hepatocellular carcinoma: The results showed that the SPP1 mRNA level in HCC cells Huh7 was significantly higher than that in human normal liver epithelial cells LO2 (Figure 6A), whereas the expression of ZBP1 and ADAMTS5 was lower than that of LO2 in Huh7 (Figures 6B, C), with a significant difference of p-value < 0.05.