Inflammation may also play an essential role in the propagation of TRPV3-mediated itchiness, as inflammatory factors such as IL-31 induce high expression of brain natriuretic peptide (BNP), activate TRPV3, upregulate expression of Serpin E1, and cause skin itching (Asakawa et al., 2006; Meng et al., 2018; Larkin et al., 2021). The gene discussed is NPPB; the disease is Pruritus.