ABCA12 and congenital reticular ichthyosiform erythroderma: Pathogenic variants in the ABCA12 gene cause various forms of autosomal recessive congenital ichthyosis (ARCI), such as severe harlequin ichthyosis (HI) and milder lamellar ichthyosis (LI) and congenital ichthyosiform erythroderma (CIE) (8).