CRP and bronchopulmonary dysplasia: In recent years, epigenome-wide association studies (EWAS) and genome-wide association studies (GWAS) have determined several loci with a different effect on BPD development in extremely low birth weight infants; such as surfactant proteins (SP-A, SP-B, SP- C) genes, Hedgehog signaling pathway genes, Toll-like receptors (TLR10, TLR1, TLR4), Oxidative stress-related genes, matrix metalloproteinase (MMPs), nitric oxide synthase (NOS2), C-reactive protein (CRP), lipopolysaccharide-binding protein (LBP), Cathepsin H and Osteonectin (22–25).