EGF and neoplasm: It has been shown that M2 macrophages produce growth factors such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF) (Asare et al. 2020; Lewis et al. 2000), which in tumors promote the growth of tumor blood vessels, so that the tumor receives an adequate blood supply.