It has been shown that M2 macrophages produce growth factors such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF) (Asare et al. 2020; Lewis et al. 2000), which in tumors promote the growth of tumor blood vessels, so that the tumor receives an adequate blood supply. This evidence concerns the gene VEGFA and neoplasm.