Serine protease inhibitor family E member 1 (SERPINE1), encoding plasminogen activator inhibitor-1 (PAI-1, a 45-kDa glycoprotein), is highly expressed in various tumors and serves as a cancer-promoting factor by facilitating tumor cell proliferation, migration, invasion, and angiogenesis in GC [24–26]. This evidence concerns the gene SERPINE1 and cancer.