Assessment of how TTN mutation influences the overall DNA repair process in cells following irradiation was carried out through the performance of neutral comet assays, revealing a significant increase in tail moment in HCT116 ‐/MUT and SW837 WT/MUT cells at 24 hours, indicating a change in DNA damage response (DDR) in TTN MUT cancer cells (Figure 3A). The gene discussed is TTN; the disease is cancer.