Consistent with previous finding, CD8 + T-cells, derived from SYT-SSX/2402-formed tumor tissues with Tcr-T1 transfer, were activated characterized by elevated expression of CD137 (Fig. 4A), while little difference of CD137 expression was observed in either CD8+ or CD4 + T-cells from both tumor and spleen tissues derived from other groups (Fig. 4A,B; Appendix Fig. S6B,C). The gene discussed is CD8A; the disease is neoplasm.