SMO and posterior cortical atrophy: Our findings on PlexinD1’s effect on Hh-Gli1 signaling in PCa cells are also consistent with recent similar observations made outside the context of malignancies, where knockdown of multiple Plexins including PlexinD1 was shown to reduce SMO agonist-induced activation of Gli1 in mouse embryonic fibroblasts (Pinskey et al, 2022).