GSEA also revealed a downregulated “Hallmark Androgen Response” gene set and a strong correlation of genes differentially expressed in human NEPC in PLXND1-high relative to PLXND1-low PCa patient tumor samples from both TCGA and SU2C/PCF 2019 cohorts (Fig. 6I). The gene discussed is PLXND1; the disease is neoplasm.