SEMA3C and posterior cortical atrophy: In addition, Tam et al showed that ectopic expression of Sema3C in RWPE-1 cells promoted the upregulation of EMT and stem markers, cell plasticity, migration and invasion in vitro, and cell dissemination in vivo (Tam et al, 2017b), which is similar to the PlexinD1-induced phenotype in PCa cells from our observations.