To test this hypothesis, we first performed GSEA demonstrating downregulation of two RTK-related GO gene signatures, “Transmembrane Receptor Protein Kinase Activity” and “Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway” in PlexinD1-knockdown versus control 22Rv1 cells, which coincided with upregulation of these two gene sets in PLXND1-high versus PLXND1-low PCa patient tumors from TCGA cohort (Fig. 7A). The gene discussed is PLXND1; the disease is posterior cortical atrophy.