POU3F2 and cancer: To test this idea, we interrogated the Cancer Cell Line Encyclopedia (CCLE), a database including gene expression data for human cancer cell lines, and identified BRN2, a neural transcription factor known as an AR-suppressed driver of NE differentiation (Bishop et al, 2017), expressed with a notably higher mRNA level in 22Rv1 cells than in other common PCa cell lines (e.g., LNCaP, PC-3, and DU145), which was corroborated by a recent study (Thaper et al, 2022).