Gli1 is a transcriptional effector at the terminal end of the Hedgehog (Hh) signaling pathway whose aberrant activation is associated with a multitude of cancers including PCa (Eichenmuller et al, 2009; Karhadkar et al, 2004; Kubo et al, 2004; Sheng et al, 2004; Watkins et al, 2003). The gene discussed is GLI1; the disease is posterior cortical atrophy.