This was corroborated by higher mRNA levels of several Gli1 target genes (PTCH1, GLI2, HHIP, BCL2, and IGFBP6) in PLXND1-high versus PLXND1-low PCa patient tumors from TCGA cohort (Fig. 8N). The gene discussed is IGFBP6; the disease is posterior cortical atrophy.