Plexins are known to activate multiple receptor tyrosine kinases (RTKs) on the cell surface to trigger downstream mitogenic signaling pathways to fuel cancer cells (Peacock et al, 2018; Toledano and Neufeld, 2023), which led us to speculate that PlexinD1 may utilize the same mechanism to provide growth and survival stimuli to CRPC cells. Here, NTRK1 is linked to cancer.