MYC and cancer: Knockdown of the nascent transcript of PVT1, a long non-coding gene located near MYC, can disrupt MYC ecDNA speckles and decrease gene expression.19 More interestingly, ecDNA aggregation and ecDNA–chromosome interaction frequency show a positive correlation, with both being regulated by caRNAs.19 Further exploration is required to understand how commonly caRNAs are involved in the ecDNA interactome in cancer.