By exploring the correlation between lnc-CHAF1B-2 and key proteins in Wnt/β-catenin D1, which correspond to the genes CTNN GSK3B and CCND1, we hypothesized that lnc-CHAF1B-2 might promote the development and progression of gastric cancer through activation of the Wnt/β-catenin pathway. The gene discussed is GSK3B; the disease is gastric cancer.