Focusing on several differential BM genes (Colq, Col22a1, and Col6a5) and proteins (Fras1, Lamc3, and Col7a1), we found that their expression correlated with the ovarian Young’s modulus as measured by SWE (Fig. 5I), which suggests that the dysregulation of BM genes may be involved in ovarian fibrosis in PCOS, contributing to increased stiffness. The gene discussed is COL22A1; the disease is polycystic ovary syndrome.