Eleven gene-sets were associated with femoral diaphysis BMFF, with the top associations being breast cancer luminal A up (P = 1.10 × 10−6), osteoclast signaling (P = 6.31 × 10−6), clock-controlled autophagy in bone metabolism (P = 3.28 × 10−5), and type 1 collagen synthesis in the context of osteogenesis imperfecta (P = 4.94 × 10−5). This evidence concerns the gene CLOCK and breast cancer.