In contrast, its expression is higher in disease states such as viral infections, autoimmune diseases and various lymphomas.301 A review of more than 1200 cases by the German Hodgkin Study Group (GHSG) revealed that 98.4% of classical Hodgkin’s lymphomas were positive for CD30, thus making it an important biomarker for lymphohaematopoietic malignancies.302. The gene discussed is TNFRSF8; the disease is lymphoma.