Duan et al. developed a Nectin-4-targeting radiotracer [68Ga]Ga-DOTA-BT009 ([68Ga]Ga-N188) based on the bicycle toxin conjugates (BTCs) BT8009 designed by Mudd et al. in 2022.245 A preclinical experiment revealed that its uptake in SW780 tumours at 1 h post-injection was 2.94 ± 0.36%ID/g, which was notably greater than the uptake in the blocking group (1.44 ± 0.17%ID/g) and the Nectin-4 negative tumours (2.02 ± 0.22%ID/g). The gene discussed is NECTIN4; the disease is neoplasm.