MAPT and frontotemporal dementia: Su et al. conducted a PET/CT study of [18F]PM-PBB3 in 35 patients with frontotemporal dementia and revealed slight deposition of the tau protein in the cerebral lobes.369 Weng et al. noted that [18F]PM-PBB3 uptake in the cerebral cortex was significantly increased in 6-month-old mice and further increased in 9-month-old mice.370 [18F]THK-5351 is a brain imaging agent developed from [18F]THK-5117 (another tau-targeting tracer).