This different pattern of joints uptake enables to distinct these rheumatic diseases, thus highlighting the potential of [99mTc]Tc-anti-CD3 scintigraphy as a valuable diagnostic tool in the clinical diagnosis of rheumatic disease.283 Another study used [89Zr]Zr-DFO-CD3 antibodies in a murine tumour xenograft model to study the response of anti-CTLA-4 immunotherapy on colon cancer, and revealed that high uptake in mice treated with anti-CTLA-4 correlated with a subsequent reduction in tumour volume. This evidence concerns the gene CTLA4 and rheumatic disorder.