TSPO and Alzheimer disease: [18F]FEPPA has been used to assess neuropsychiatric diseases; it shows increased binding in the white and grey matter of AD patients, and elevated uptake in the cortico-striatal-thalamic circuit involving the orbitofrontal cortex of OCD patients.385 [11C]DPA-713 also shows a relatively high signal‒to‒noise ratio and selective binding to human TSPO.