FAP and heart failure: Detection of FAP in myocardial tissue allows early identification of cardiac injury due to increased FAP expression in activated myocardial fibroblasts, and FAPI has been extensively explored clinically in cardiovascular diseases such as infarction, heart failure, tumour treatment-related cardiotoxicity, and cardiomyopathy.103 Zhang et al. performed [68Ga]Ga-FAPI-04 PET/MR on 26 patients with advanced cardiac infarction and reported that FAPI uptake was significantly greater in the left ventricular remodeling group.