Wang et al. labelled GPC3-targeting peptide L5 with 5-carboxyfluorescein (FAM) and Al18F, yielding [18F]AlF-NOTA-MP-6-Aoc-L5, which clearly represented imaging visualization but a low tumour-to-liver ratio (0.93 ± 0.16).236 Therefore, the chemical structure of the GPC3-targeting radiotracer remains to be modified to reduce its liver accumulation. This evidence concerns the gene GPC3 and neoplasm.