[11C]dihydrotetrabenazine ([11C]DTBZ) is an efficient PET tracer for imaging VMAT2, and it has been successfully evaluated in patients with AD and dementia with Lewy bodies.427 Considering the short half-life of carbon-11 (t1/2 = 20 min), 18F- fluorinated (t1/2 = 110 min) fluoropropyl analogues, namely, [18F]FP-( + )-DTBZ (also known as [18F]AV-133), with better clinical availability for PET/CT imaging of VMAT2, have been developed. Here, SLC18A2 is linked to Alzheimer disease.