Bulk mRNA analysis from whole tissue extracted from SG of patients affected by either SjS or Sicca confirmed that IFNG, CXCL9, CXCL13, CCL19, CD40, and TNFSF13B were all expressed at significantly higher levels in SjS compared to Sicca (Fig. 4d). The gene discussed is TNFSF13B; the disease is Schwartz-Jampel syndrome.