INS and obesity due to melanocortin 4 receptor deficiency: Here, we report that endothelial IGF-1R knockdown in the setting of obesity blunts the deleterious remodelling of eWAT (the equivalent of the visceral depot in humans) in response to high fat feeding with smaller adipocytes, generally considered a healthier phenotype than larger adipocytes, contributing to insulin resistance14,48–52.