An in-depth examination of the Crtap−/− murine model of OI revealed a series of periodontal dysfunction including decreased alveolar bone volume and mineral density, increased PDL space, ectopic calcification within the PDL, bone-tooth ankylosis, altered immunostaining of extracellular matrix proteins in bone and PDL, increased pSMAD5, and more numerous osteoclasts on alveolar bone surfaces. Here, CRTAP is linked to osteogenesis imperfecta.