Although, activated HSCs are the dominant contributor of ECM production that causes fibrosis in mouse models of toxic, cholestatic and fatty liver diseases (Mederacke et al, 2013), our RNA-seq data showed ECM organization genes were upregulated in primary BECs isolated from Rage control mice when compared to the mutant counterpart (Fig. 2F). The gene discussed is AGER; the disease is fatty liver disease.