Of clinical significance, we also found that both mRNA and protein levels of FBXW7 were increased in subcutaneous WAT of obese human, and was negatively correlated with Ucp1 levels (Fig. 1D; Appendix Fig. S1H,I), suggesting FBXW7 is involved in the suppression of thermogenic functions and the development of obesity. Here, FBXW7 is linked to obesity due to melanocortin 4 receptor deficiency.