To narrow down the compartment in which inflammasome activity influences lymphoma progression, we performed mixed fetal liver chimera experiments reconstituting lethally irradiated recipient WT or Casp1−/−Casp11−/− with a 9:1 ratio of B cell deficient μMT WT or μMT/Casp1−/−Casp11−/− and Eμ-myc or Eμ-myc/Casp1−/−Casp11−/− bone marrows as depicted in Fig. 2b. The gene discussed is CASP1; the disease is lymphoma.