This increased protein expression mirrored the increased transcript expression levels of Ras pathway related (Kinase suppressor of Ras1 Ksr1, Synaptic Ras GTPase-activating protein 1 Syngap1, Abl1 proto-oncogene, Ras protein activator like 1 Rasal1, and T cell lymphoma invasion and metastasis 1 Tiam1) and also cancer related genes (Pdgfrb, Notch1, Cbl proto-oncogene, Trio and Ras homology family member b Rhob) in Casp1−/−Casp11−/− and Eμ-myc Casp1−/−Casp11−/− LSK HSCs (Fig. 4h). The gene discussed is CASP1; the disease is cancer.