EV transfer of DOC2B, and associated tumor suppressive functions could be linked to (i) morphological changes, senescence, anoikis, G0/G1 to S phase arrest, ROS, intracellular calcium, lipid droplet accumulation, and lipid peroxidation, and (ii) EMT inhibition and ERK1/2 activity reduction in recipient CC cells. This evidence concerns the gene DOC2B and neoplasm.