Similarly, the GO analysis of the GWAS catalog reported genes using the Gene2Func function of FUMA GWAS tool has shown a significant association of PRDM16, TGFBR2, CTNNB1, PRDM8, ESR1, GLIS Family Zinc Finger 3 (GLIS3), CACNB2, Zinc Finger Protein 365 (ZNF365), TCF7L2, FTO, ACE, HMGCR, TIMD4, HLA-G, N-Acetyltransferase 2 (NAT2), and CACNB2 with various risk factors of T2D including blood pressure, LDL cholesterol levels, Apolipoprotein B levels, triglyceride levels, circulating leptin levels, fasting insulin levels, total cholesterol levels, and blood glucose levels (Supplementary Table 7). This evidence concerns the gene LEP and type 2 diabetes mellitus.