The epistatic analysis revealed that the variant of the Calcium Voltage-Gated Channel Subunit Alpha1 C (CACNA1C) gene showed interaction with the Interleukin 1 Beta (IL1B), Fibrinogen Alpha Chain (FGA), T Cell Immunoglobulin And Mucin Domain Containing 4 (TIMD4), Major Histocompatibility Complex, Class I, G (HLA-G), 5-Hydroxytryptamine Receptor 1B (HTR1B), Poliovirus receptor-related 2 (PVRL2), and Transmembrane Serine Protease 6 (TMPRSS6). The interaction analysis further depicted the elevated risk at higher significance levels with T2D in the population. The gene discussed is TMPRSS6; the disease is type 2 diabetes mellitus.