Moreover, the present study identified the genetic variants in the TMEM57, RP11-227F8.2, PRDM16, IL1B, SULT1C4, SCN5A, TGFBR2, CTNNB1, PRDM8, FGA, TENM3, TIMD4, HMGCR, HLA-G, HTR1B, ESR1, BACH2, TAS2R38, Activator Of Transcription And Developmental Regulator AUTS2 (AUTS2), GNG11, LOC101927609, NAT2, GLT6D1, GLIS3, CACNB2, TCF7L2, ZNF365, IL18, DRD4, CACNA1C, SIX1, CHRNA5, FTO, RP11-2L4.1, STARD3, ACE, PVRL2, AC011526.1, RP5-881L22.5, TMPRSS6, and RP3-438O4.4 associated with risk of T2D. This evidence concerns the gene ESR1 and type 2 diabetes mellitus.