NFKB1 and neoplasm: In addition, the highly expressed long noncoding RNA Uc003xsl.1 and miRNA-301a-3p directly bind to NKRF, disrupting its negative regulation of NF-κB-responsive genes to influence patient prognosis in triple-negative breast cancer and gastric cancer, respectively, and targeting these upstream mediators of NKRF could prevent tumor progression43,44.