Remarkably, conditional knockout of Gclm during the late stages in the AOM/DSS mouse model reduced the multiplicity of large adenomas and the total load of adenomas (Fig. 6a), with reductions in both the number and volume of tumors compared with those in WT mice, and the suppressive effects were more significant following oxaliplatin treatment (Fig. 6b and Supplementary Fig. 6e). The gene discussed is GCLM; the disease is adenoma.