PANK4 and cancer: We found that several intermediate metabolites of the CoA synthesis pathway (e.g., 4’-Phosphopantetheine and 3’-Dephospho-CoA) were increased in PanK4 mKO muscles (Fig. 2C–E & Fig. S4A), supporting recent findings in cancer cells that PanK4 might act as a potential repressor of the CoA pathway17.