Overall, this study supports a model of ISC regulation whereby Myc expression may largely be associated with the Wnt pathway during homeostasis, but in the setting of immune-mediated GI damage occurring in GVHD, T cells and IFNγ-driven STAT1 signaling can play a prominent role in regulating this stem cell program (Fig. 7). The gene discussed is STAT1; the disease is graft versus host disease.