IFNG and graft versus host disease: Additionally, GSEA comparing ISC clusters after allo-BMT and syn-BMT also identified the Hallmark Interferon Alpha Response as a potentially enriched pathway in GVHD (Fig. 1f), although there was limited evidence for upregulation of unique IFNα gene targets within this gene set (Supplementary Fig. 1f), suggesting that the identification of the IFNα pathway may have been driven by the IFNγ-associated genes included in the IFNα Hallmark gene set.