In two hemochromatosis mouse models that develop severe iron overload (Hjv–/– and Smad4Alb/Alb mice), elevated liver iron was associated with increased lipid peroxidation (MDA), decreased NADPH and liver damage that was attenuated with ferrostatin-1 treatment.24 This study also conducted microarray analyses of iron-treated bone marrow–derived macrophages and identified Slc7a11 as a candidate gene of ferroptosis in hemochromatosis, however future studies are required to characterise ferroptosis vulnerability in the human hemochromatosis population. Here, HJV is linked to hemochromatosis type 1.