GPX4 expression is essential for the function of a range of different immune cells including CD8+ and CD4+ T cells, which fail to expand and protect against acute lymphocytic choriomeningitis virus and Leishmania major parasite infections when lacking Gpx4.149 Dendritic cells fail to secrete pro-inflammatory cytokines (TNF and IL6) and express MHC class I in response to the maturation signal of lipopolysaccharide upon GPX4 inhibition by RSL3.150. This evidence concerns the gene GPX4 and infection.