GPX4 and familial pancreatic carcinoma: In addition, copper treatment accelerated ferroptosis-induced tumour suppression in a mouse model of pancreatic cancer, which was associated with decreased expression of GPX4.172 Copper induced GPX4 deficiency may be relevant to copper overload conditions like Wilson’s Disease, an autosomal recessive genetic disease (mutation of ATP7B) characterized by copper overload and degeneration in multiple organs including the liver and brain.