AKT1 and cancer: SREBP1 has been reported to be regulated by PI3K-AKT-mTOR signalling,287,288 one of the most commonly altered signalling pathways in human cancers.289–291 As a result, oncogenic activation of the PI3K-AKT-mTOR signaling pathway induces protection against ferroptosis and pharmacological inhibition of this pathway could induce vulnerability to ferroptosis induction in cancer cells.292 A study looking at the impact of SREBF1 knockout, identified reduced expression of Stearoyl-CoA Desaturase 1 (SCD1, both mRNA and protein levels) as the most significantly impacted target.