GPX4 and tuberculosis: M. tuberculosis has also been shown to promote dissemination of ferroptosis by the secretion of protein tyrosine phosphatase A, which enters a host cell nucleus to promote asymmetric dimethylation of histone H3 arginine 2 via targeting protein arginine methyltransferase 6 leading to the inhibition of GPX4 expression.145,146 While key findings have been replicated in a mouse model of tuberculosis,144 the translation to human tuberculosis remains to be investigated.