In addition to iron accumulation and excessive lipid peroxidation, further ferroptosis vulnerability in PD is demonstrated by a depleted glutathione levels, decreased system xc- and diminished coenzyme Q10.390 In a mouse model of PD, GPX4 levels were decreased in midbrain dopaminergic neurons.391 The proposed mechanism suggested that iron-induced dopamine oxidation modified GPX4 leading to its degradation. Here, GPX4 is linked to Parkinson disease.