Gene set enrichment analysis (GSEA) of the entire scRNAseq dataset unexpectedly revealed IFNγ-signalling and related pathways such as antigen presentation as top hits from both hallmark and Reactome databases of immune cells from IFNγRKO tumours (Fig. 3C, D), suggesting that a highly inflammatory environment emerges following IFNγR deletion in tumour cells. Here, IFNGR1 is linked to neoplasm.