In addition, inhibition of monocyte recruitment, through CCR2 deletion, resulted in CD8+ T cell and NK cell expansion in WT, but not IFNγRKO, tumours (Fig. 5D), suggesting that loss of phenotypically immunosuppressive macrophages in WT tumours (Fig. 4A–C) aids in unleashing lymphocyte activity, which in turn improves WT tumour control45,46. This evidence concerns the gene CD8A and neoplasm.