In ICB-sensitive models such as MC38 murine colon adenocarcinoma, anti-PD-L1 drove a significantly more pro-inflammatory macrophage phenotype compared to untreated tumours, and IFNγR−/− bone marrow transferred into tumour-bearing WT mice were only able to produce M2-like macrophages63. The gene discussed is CD274; the disease is colon adenocarcinoma.