JAK1 and neoplasm: To explore whether this is also elicited in human tumours, we elected to investigate whether enrichment scoring using a combined CD8-monocyte signature would be increased in TCGA RNAseq datasets in which the patient tumours harboured mutations in IFNGR1/2, JAK1/2, or STAT1. Only datasets in which the calculated variant consequences (i.e. VEP IMPACT score) deemed high or moderate were included for analysis.