Finally, GABA type A receptor–associated protein like 1 gene (GABARAPL1), coding for GABARAP structural protein of the autophagosome, was the only shared target gene between PI3Kα signature, PI3Kβ signature, compressive stress signature, and “PI3K-AKT REACTOME signaling pathway in cancer” signature (Fig 5B). Here, PIK3CA is linked to cancer.