Further, TLL1 is a member of the BMP1/TLD (bone morphogenetic protein1/tolloid)-like proteinase family; BMP1 controls latent TGF-β activation via the cleavage of LTBP1 (latent TGF-β binding protein-1) [36], and TGF-β plays important roles in cancer progression [37]. This evidence concerns the gene TLL1 and cancer.