Multivariable Cox proportional hazard regression analysis showed that Ki-67 index (HR 3.28, 95% CI 1.04–10.32, p = 0.042), lymphovascular invasion (HR 2.97, 95% CI 1.03–8.6, p = 0.044), and tChoi (HR 2.69, 95% CI 1.02–7.09, p = 0.046) were significantly predictive of 10-year DFS in patients with HR+/HER2- breast cancer. The gene discussed is MKI67; the disease is breast cancer.