Zincis widely implicated in transcriptional activation via ZNFs743 and in various signaling pathways in cancer.744 For example, the zinc finger protein p66βis a coactivator of the zinc finger transcription factor Snail, whichplays crucial roles in the regulation of cell plasticity during developmentand in cancer.745 Cancer cell plasticitycan give rise to a cell state refractory to standard-of-care treatments,constituting a drug-tolerant persister state. This evidence concerns the gene ZNF146 and cancer.