Thechemical composition of diseased tissues has been shown to be distinctfrom that of healthy tissues, for example, with the abundance of hyaluronanin the stroma of pancreatic tumors and in the lung of severe COVID-19patients,448,449 which argues for the prevalenceof CD44-mediated iron uptake over other mechanisms, and this playsa role in the control of cell identity by iron in cancer and inflammation.446,450,451. This evidence concerns the gene CD44 and cancer.