CGAS and melanoma: cGAS-STING is also involved in immune sensingin the context of cancer.429 For instance,it was reported that manganese enhances cancer detection by the innateimmune system.430 Indeed, manganese-loadednanoparticles enhance cGAS-STING activation, which holds great potentialfor cancer immunotherapy.431 The cytokineinterleukin-2 (IL-2) is used to treat malignant melanoma and metastaticrenal cell carcinoma.