Changes of cell states underpinmany biological processes, such as EMT11,445 and noradrenergic-to-mesenchymaltransition in cancers,524 contributingto cancer metastases and the acquisition of a DTP cancer cell state.Other processes involving cell-state transitions include the activationof immune cells,13 including macrophagepolarization.525 CD44 has been associatedwith these processes and is a reliable marker of cell plasticity,playing a central role in metal import and thus cell signaling. Here, CD44 is linked to cancer.